For internal URLs:
$urlpath = Read-Host "Type internal Client Access FQDN starting with http:// or https://"
Set-ClientAccessServer –Identity * –AutodiscoverServiceInternalUri “$urlpath/autodiscover/autodiscover.xml”
Set-webservicesvirtualdirectory –Identity * –internalurl “$urlpath/ews/exchange.asmx”
Set-oabvirtualdirectory –Identity * –internalurl “$urlpath/oab”
Set-owavirtualdirectory –Identity * –internalurl “$urlpath/owa”
Set-ecpvirtualdirectory –Identity * –internalurl “$urlpath/ecp”
Set-ActiveSyncVirtualDirectory -Identity * -InternalUrl "$urlpath/Microsoft-Server-ActiveSync"
External URLs:
Set-ClientAccessServer –Identity * –AutodiscoverServiceExternalUri “$urlpath/autodiscover/autodiscover.xml”
Set-webservicesvirtualdirectory –Identity * -ExternalUrl “$urlpath/ews/exchange.asmx”
Set-oabvirtualdirectory –Identity * –ExternalUrl “$urlpath/oab”
Set-owavirtualdirectory –Identity * –ExternalUrl “$urlpath/owa”
Set-ecpvirtualdirectory –Identity * –ExternalUrl “$urlpath/ecp”
Set-ActiveSyncVirtualDirectory -Identity * -ExternalUrl "$urlpath/Microsoft-Server-ActiveSync
save it as a .ps1 extension and run it in Exchange Management Shell